Principal Scientist: PKDM-BA (Small molecule in vitro ADME group lead)

Career CategoryResearchJob DescriptionPrincipal Scientist - Pharmacokinetics and Drug Metabolism (Small molecule In vitro ADME group lead)LiveWhat you will doLet’s do this. Let’s change the world. In this role we are seeking a highly motivated scientist to lead a group of in vitro ADME scientists in Pharmacokinetics and Drug Metabolism (PKDM) team at our upcoming research facility in India. The successful candidate will bring strong hands-on expertise in in vitro ADME assays, high-throughput screening, and a strong desire to involve in mechanistic ADME assay development to support small molecule drug discovery projects. This role requires both scientific excellence and team management skills to foster collaboration, innovation, and operational efficiency. In this role, your core responsibilities include:Involve and mentor a team of scientists in the design, execution, and interpretation of in vitro ADME studiesDevelop, optimize, validate, and implement mechanistic in vitro assays to characterize drug metabolism, transporter interactions, and drug–drug interaction (DDI) riskDesign, establish, and validate robust high-throughput screening workflows to support compound profiling and lead optimization effortsOversee the execution and interpretation of a comprehensive suite of in vitro ADME assays, including:Metabolic stability assessments using liver microsomes, S9 fractions, and hepatocytesBinding assaysCYP450 inhibition and induction studiesTransporter uptake and efflux assaysIn vitro drug–drug interaction (DDI) evaluationsManage and maintain cell culture platforms supporting ADME studies, including primary hepatocytes, immortalized cell lines, and transporter-transfected cell systems, ensuring model suitability and reproducibilitySupervise permeability and absorption studies using established in vitro models to assess compound absorption potentialEnsure data quality, integrity, reproducibility, and timely delivery of results across all in vitro ADME activities, in alignment with internal standards and project timelinesEnsure compliance with applicable regulatory guidelines, safety requirements, and internal quality systems, maintaining thorough and audit-ready documentationDevelop team members, fostering a culture of scientific rigor, continuous improvement, and innovationPreferred Qualifications:PhD or Masters with 12+Years in Pharmacokinetics, Pharmaceutical Sciences, or related fieldsStrong hands-on experience in developing mechanistic in vitro ADME models (e.g. enzyme kinetics, DDI and transporter assays etc) and interpreting complex datasetsProven track record in high-throughput screening and assay automationTeam management skillsExcellent communication, collaboration, and problem-solving abilitiesStrong publication or project track record in ADME/DMPK research is a plus.