Program Manager II (Human Research Operations)

Site: The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job SummaryThe Division of Neuropsychiatry and Interventional Psychiatry at Mass General Brigham and Harvard Medical School integrates research, innovation, clinical care, and training across a large and dynamic clinical neuroscience portfolio.Reporting to the Division Chief, the Program Manager for Research Operations will lead the execution and operational infrastructure of the Division’s research portfolio, ensuring that studies, grants, and scientific outputs progress reliably from initiation through completion.This role serves as the operational backbone for research activities, building systems, enforcing timelines, and overseeing day-to-day research operations. The Program Manager partners closely with research staff, faculty, and institutional teams, ensuring high-quality, compliant, and efficient study execution within a structured and scalable operational framework. Qualifications. Human Research Operations & Team LeadershipOversee study execution across the full research lifecycle, including:protocol development and study start-upactive study operationsparticipant enrollment and study visitsstudy closeout and reportingDirectly supervise a team of research assistants and junior staff, including hiring, onboarding, supervision, task allocation, performance management, and professional development.Ensure appropriate staffing, coverage, and workload allocation across studies.Provide ongoing coaching and guidance to research staff to support high-quality study execution and day-to-day operational reliability across studies.Serve as the primary operational point of contact for study teams, resolving day-to-day issues and ensuring smooth coordination across projectsSupport preparation and coordination of administrative and regulatory components of grant applications, working with investigators and pre-/post-award teams to ensure completeness, alignment with study operations, and timely submission2. Research Execution Systems & InfrastructureDevelop and maintain systems to support research operations, including:project and portfolio tracking toolsdashboards and reporting frameworksSOPs and standardized workflowsDefine and implement metrics to monitor study launch, progress, recruitment, and performanceMaintain structured dashboards and trackers that identify project status, upcoming milestones, risks, and dependencies, and ensure this information is current and actionableBuild scalable infrastructure that can be adopted across the division3. Project & Portfolio ExecutionTranslate research priorities into structured work plans with:timelinesownershipdeliverablesTrack progress across projects and ensure adherence to milestones and deadlinesIdentify delays, bottlenecks, and risks early and implement corrective actionsWork closely with investigators and study teams to ensure alignment and executionActively enforce follow-through and accountability across research workstreams4. Regulatory Compliance, Governance, & Quality OversightOversee regulatory and compliance processes, including:IRB submissions, amendments, and renewalsprotocol deviations and reportable eventsmaintenance of required regulatory documentationadherence to Good Clinical Practice (GCP) standardsImplement and maintain quality and compliance systems across studies, including regulatory oversight, data quality assurance, and protocol adherence across studiesEnsure compliance with institutional, NIH, and sponsor requirementsCoordinate with institutional compliance and research administration officesEnsure research staff maintain required certifications and are appropriately trained in and adhere to Good Clinical Practice (GCP) standards and institutional compliance requirements; monitor compliance and address gaps as needed5. Administrative Systems & Operational SupportDelegate execution of administrative tasks to research assistants or administrative staff and ensure appropriate oversight and completionBuild and maintain systems for:onboarding and training workflowsequipment and inventory trackingoperational logs and reportingEnsure reliability, completeness, and efficiency of operational processes6. Cross-Functional Coordination (Research Interface)Ensure research operations are executed in accordance with divisional priorities, coordinating with division leadership and relevant functional leads as neededCoordinate dependencies between research operations and related functions (innovation teams, data/analysis, grants/finance, and executive operations), ensuring timelines and deliverables remain alignedEnsure research timelines are coordinated with grant submission cycles, data availability, and other operational dependenciesFacilitate communication across teams to resolve operational issues and maintain momentum on shared workstreams Additional Job Details (if applicable)QualificationsRequiredDegree in life sciences, public health, healthcare administration, or related field5+ years of experience in human research operations, clinical trials, or research program managementDemonstrated expertise in regulatory compliance and GCP standardsExperience with study management systems (e.g., REDCap, OnCore)Experience building operational systems (dashboards, workflows, SOPs)Strong project management, organizational, and leadership skillsPreferredProject Management Professional (PMP) or equivalent certification.Certified Research Administrator (CRA), or equivalent certificationExperience in academic medical centers or