Senior Scientist, Respiratory Discovery

Job DescriptionThe Senior Scientist will join the Respiratory Biology Discovery group and contribute to target identification, translational biology, and mechanism‑of‑action studies supporting early discovery programs in chronic lung diseases, including COPD, bronchiectasis, asthma, pulmonary fibrosis, and inflammatory airway diseases.The successful candidate will apply human‑relevant in vitro and ex vivo experimental systems, with an emphasis on primary airway epithelial biology, mesenchymal and immune‑epithelial interactions, disease‑relevant functional assays, and translational biomarkers. This individual will generate high‑quality mechanistic datasets, support biomarker discovery and translational efforts, and collaborate closely within multidisciplinary discovery and translational teams.Key Responsibilities:Design, execute, and interpret in vitro and ex vivo studies to support respiratory target validation and translational biology programsDevelop and apply human‑relevant experimental systems, including primary airway epithelial cultures, air‑liquid interface (ALI) models, immune cell assays, and co‑culture platformsGenerate mechanistic and disease‑relevant datasets using molecular, cellular, imaging, and biomarker‑based approachesApply imaging techniques, including immunohistochemistry (IHC), immunofluorescence (IF), and high‑content imaging, with image‑based analysis to interrogate epithelial and inflammatory biologyPerform and interpret flow cytometry/FACS‑based immune and cellular phenotyping studiesSupport translational biomarker discovery and validation using multiplex immunoassay platforms (e.g., Meso Scale Discovery, Luminex, Olink)Conduct molecular and cellular biology assays, including cell culture, PBMC isolation, PCR/qPCR, nucleic acid extraction, protein detection, and functional cellular assaysCharacterize disease‑relevant biological pathways in chronic lung diseases, including inflammatory, epithelial, fibrotic, and immune mechanismsGenerate reproducible, high‑quality datasets to inform project decisions, translational hypotheses, and program progressionCommunicate scientific findings effectively through presentations, data reviews, and written reportsCollaborate closely across biology, pharmacology, DMPK, and translational/clinical functions within a matrixed discovery environmentQUALIFICATIONS:Education:Bachelor's (with 7+ years), Master's (with 4+ years) or Ph.D. biology, immunology, pharmacology, physiology, pulmonary biology or related discipline and relevant experienceRequired Experience and Skills:Demonstrated expertise in primary human cell culture systems, particularly airway epithelial biology and/or air-liquid interface (ALI) culturesStrong hands-on wet lab experience in molecular and cellular biology techniquesExperience with flow cytometry/FACS and multiplex biomarker platforms (e.g., Meso Scale Discovery, Luminex, Olink, AlphaLISA)Expertise in imaging‑based approaches, including immunohistochemistry (IHC), immunofluorescence (IF), immunocytochemistry (ICC), histology, and image analysisAbility to independently design, execute, troubleshoot, and interpret experimental studiesSolid understanding of respiratory disease biology, including inflammatory and epithelial mechanisms relevant to chronic lung diseasesStrong written and verbal scientific communication skills with ability to present and discuss data in cross-functional settings Preferred Experience and Skills:Prior experience in respiratory drug discovery and translational research environmentsExperience with immune-epithelial co-culture systems and/or macrophage biologyFamiliarity with transcriptomic datasets, including bulk or single-cell RNA sequencingExperience with barrier function assays (TEER), live-cell imaging, or spatial biology approaches#EligibleforERP Required Skills: Cell Cultures, Cell Culture Techniques, Cellular Biology Techniques, Ex Vivo, Flow Cytometry, Imaging Techniques, Immunohistochemistry (IHC), Immunology, In Vitro Studies, Molecular Biology, Primary Cell Culture, Pulmonary Disease ResearchPreferred Skills: Current Employees apply HERECurrent Contingent Workers apply HEREUS and Puerto Rico Residents Only:Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.  As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.  For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:EEOC Know Your RightsEEOC GINA Supplement​We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.Learn more about your rights, including under California, Colorado and other US State ActsThe salary range for this role is$131,400.00 - $206,800.00This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business