Senior Scientist – In Vivo Neuroimmunology

Job DescriptionOur company's Neuroscience is recruiting a Sr. Scientist in our Neuroimmunology team in Boston, MA to lead in vivo model development and validation to advance novel immune-based therapies for CNS diseases. As a Sr. Scientist, you will apply your expertise to evaluate PK/PD and disease-relevant endpoints in murine models to advance pipeline programs. This lab-based role requires independent ownership of study design, execution, sample processing and evaluation, data analysis, and clear communication of results to cross-functional project teams and stakeholders. The successful candidate will be able to work independently as well as proactively collaborate with colleagues to generate high-impact data to drive decision making and advance drug discovery.Key responsibilities of the In Vivo Neuroimmunology Sr. Scientist include:Design, execute, and report murine in vivo studies addressing target validation, mechanism of action, PK/PD, and translational biomarkers; take end‑to‑end ownership of study planning and documentation.Perform and supervise dosing (IV, IP, PO, SC and other routes), blood collection, cardiac perfusion, and careful dissection/collection of CNS and peripheral tissues.Prepare and fractionate tissues for biochemical and molecular assays (soluble/insoluble protein fractions) and execute immunoassays and RNA analyses (e.g. ELISA, OLINK, NULISA, western blot, flow cytometry, qPCR/RT‑qPCR, bulk and single-cell RNA sequencing).Process, curate, and analyze datasets; apply statistical and computational tools to generate figures, study reports and presentations that inform program decisions.Troubleshoot and optimize experimental and analytical workflows, validate new methods, ensure reproducibility, and maintain accurate records.Communicate results clearly to project teams and the broader scientific community (internal reports, presentations, and publications), and uphold laboratory safety, animal welfare and regulatory compliance while collaborating across functions and with external partners. Work environment and travel:This is an on‑site, laboratory position based in Boston. Occasional travel (QUALIFICATIONS:Education:Master's (with 5+ years) or Ph.D. (with 1 year) in Neuroscience, Molecular Cell Biology, Pharmacology, Biology or related field with relevant experience Required Experience and Skills:Demonstrated hands‑on experience designing and executing rodent in vivo experiments including stereotaxic surgeries (intracerebral and intracerebroventricular injections)Proficiency with multiple routes of dosing, blood collection methods, cardiac perfusion, and dissection of CNS (discrete brain regions, spinal cord) and peripheral tissuesPractical experience preparing tissue fractions (soluble/insoluble proteins) and performing biochemical and molecular assays (e.g. ELISA, OLINK, NULISA, western blot, RNA sequencing or qPCR)Experience independently analyzing and visualizing experimental data including from multiplexed platformsStrong written and oral communication skills; ability to prepare study reports and present findings to diverse audiencesAbility to work independently within a collaborative, cross‑functional teamPreferred Experience and Skills:Industry drug‑discovery experience in pharmaceutical or biotech settingsHands‑on proficiency with murine procedures including CSF collection and osmotic‑pump implantation/managementExperience with inflammatory and neurodegenerative transgenic mouse models or with PK/PD and dose–response study design/interpretationExperience designing and executing sequencing studies (i.e. bulk RNAseq, scRNAseq or snRNAseq), working knowledge of data analysis tools (Python and/or RStudio preferred) and experience generating figures/reportsExperience mentoring or supervising early‑career scientists and collaborating across functional teamsRecord of contributions to scientific publications or presentations#EligibleforERPRequired Skills: Biology, Blood Specimen Collection, Cardiac Perfusion, Dosing, In Vivo Animal Models, In Vivo Experiment, In Vivo Studies, Molecular Biology, Neuroscience, Neuroscience Research, Pharmacology, Stereotaxic SurgeryPreferred Skills: Current Employees apply HERECurrent Contingent Workers apply HEREUS and Puerto Rico Residents Only:Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.  As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.  For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:EEOC Know Your RightsEEOC GINA Supplement​We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.Learn more about your rights, including under California, Colorado and other US State ActsThe salary range for this role is$119,100.00 - $187,500.00This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifica