Senior Scientist, In Vivo Pharmacology, Inflammation Research (Respiratory Focus)

Career CategoryScientificJob DescriptionJoin Amgen’s Mission of Serving PatientsAt Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.Senior Scientist, In Vivo Pharmacology, Inflammation Research (Respiratory Focus)What you will doLet’s do this. Let’s change the world. In this vital role you will lead a highly dynamic in vivo pharmacology team executing in vivo preclinical disease models and in vitro assays in the vivarium and lab supporting pipeline programs managing interactions and presentation of results with project teams and collaborators.Key Responsibilities:Lead and perform hands-on in vivo work and run concurrent studies mice/possibly ratsServe as manager with at least two direct reports Scientist and Associate ScientistsDesign experiments, oversee study execution, and ensure studies are completed on scheduledAct as in vivo PTR on project teams: represent and communicate in vivo data to project teams and departmentMentor, support, and manage direct reports performance, development, supervisionMaintain organization, attention to detail, and study preparationParticipate in panels/seminars as part of interview/hiring and in broader scientific communication as neededParticipate in weekend/evenings dosing rotations when required.What we expect of youWe are all different, yet we all use our unique contributions to serve patients. The Senior Scientist we seek is a driven, pro-active, independent, and enthusiastic scientist who wants to contribute to cutting edge science and serve patients in a highly productive team environment, with strong understanding of Immunology and Inflammation biology and principles.Basic Qualifications:Doctorate degree PhDORPharmDORMD and Immunology experienceORMaster’s degree and 3 years of f Immunology or related experienceORBachelor’s degree and 5 years of f Immunology or related experiencePreferred Qualifications:Willingness and curiosity to learn and explore new areas of researchSignificant experience executing in vivo preclinical respiratory disease models, including asthma (OVA, HDM), COPD (Elastase, smoke extract), Bleomycin fibrosis (i.t., i.d., s.c.), respiratory virus infection (PR8)Experience with preclinical inflammatory disease models, including colitis, lupus, RA, PBC importantSignificant hands-on expertise in animal (mouse and rat) handling and in vivo techniques (i.v., i.p., p.o., i.d., s.c., i.t., bleeds, necropsy)Significant Experience with lung function measurements (FlexiVent, Plethysmography), imaging (mCT), and inhaled drug deliveryHands-on experience in cellular, biochemical, histological, and molecular biology assay techniques (i.e. ELISA, MSD, quantitative RT-PCR, BCA protein measurements)Hands-on experience with multicolor flow cytometry including Spectral flow approaches and Immune cell populations is essentialComputer literacy, especially proficiency with GraphPad Prism, Excel, PowerPoint and WordAttention to detail, excellent organizational and communication skills, accurate & timely record keeping and data analysis are essential.Demonstrated track record of independent critical thinking and scientific achievement.Demonstrated experience in and understand of pharmacology with application using in vivo models of inflammation/ImmunologyExperience working on project teams leading in vivo contributionsExperience managing an in vivo pharmacology team or direct reports (2 years)Ability to work in a flexible team-oriented environment. Weekend and evening work may be required.What you can expect from usAs we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accountsA discretionary annual bonus program, or for field sales representatives, a sales-based incentive planStock-based long-term incentivesAward-winning time-off plansFlexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.Apply now and make a lasting impact with the Amgen team.careers.amgen.comIn any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates