Senior Research Associate – Targeted LNP Formulation (Non-Viral Delivery)

Working with UsChallenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.We are seeking a highly motivated Senior Research Associate to join the Non-Viral Delivery team to support the development of next-generation targeted lipid nanoparticle (tLNP) systems for nucleic acid therapeutics.In this role, you will contribute to the design, execution, and optimization of formulation strategies to enable efficient and selective delivery to defined cell types. You will take on increased ownership of experimental workflows, generate high-quality datasets to guide program decisions, and collaborate closely with cross-functional teams spanning biology, analytical development, and process sciences.This hands-on, laboratory-based role is ideal for a scientist who thrives in a fast-paced, highly collaborative environment and is excited to contribute to both program advancement and platform innovation.Key ResponsibilitiesFormulation Development & OptimizationDevelop and optimize targeted lipid nanoparticle formulations for delivery of nucleic acid cargosEvaluate formulation parameters influencing delivery performance, including composition, ligand density, and process parameters.Support the generation of lipid nanoparticles for in vitro and in vivo studies, ensuring consistency, quality, and reproducibility.Perform physicochemical, biophysical, and functional characterization of LNPs and conjugates using analytical techniques such as particle sizing (DLS), zeta potential, UV-Vis and fluorescence spectroscopy, and chromatographic or electrophoretic methods (e.g., HPLC, SDS-PAGE, LC/MS)Analyze, interpret, and effectively communicate experimental findings through presentations, written reports, and active engagement in scientific discussions and team meetingsPartner closely with teams in biology, immunology, analytical development, and process development to advance programs.Maintain accurate and detailed experimental records while contributing to the improvement of laboratory workflows, robustness, and throughput of formulation and characterization processes.Required QualificationsB.S. or M.S. in Chemical Engineering, Bioengineering, Pharmaceutical Sciences, Chemistry, Biochemistry, or a related field.Typically 2–5+ years of relevant experience in an industry or applied research setting.Demonstrated hands-on experience with design, synthesis, and characterization of nanoparticle formulations in an industry environment is required.  Familiarity with targeted delivery approaches, including ligand conjugation and nanoparticle surface functionalization strategies.Proficiency in formulation characterization techniques, including dynamic light scattering, zeta potential, UV-Vis and fluorescence spectroscopy, and chromatographic methods.Strong understanding of experimental design and ability to troubleshoot and optimize workflows.Exposure to statistical design of experiments (DoE) and data analysis tools.Demonstrated ability to work both independently and collaboratively in a team environment.Strong organizational skills and attention to detail in data recording and execution.If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.Compensation Overview:Cambridge - MA - US: $110,810 - $134,281 The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/. Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:Health Coverage: Medical, pharmacy, dental, and vision care.Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.​Work-life benefits include:Paid Time OffUS Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidaysBased on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per ye