Scientist

Working with UsChallenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.The Protein Homeostasis Thematic Research Center at BMS is a fundamental Oncology research engine delivering oncology and hematology therapeutics to patients. The TRC has a major focus on exploiting BMS’ expertise in protein degradation to discover and develop therapies aimed at tumor intrinsic vulnerabilities and mechanisms of resistance to existing cancer therapeutics. This focus on protein degradation allows us to attack protein classes that were previously deemed undruggable.Position SummaryBMS is seeking a Scientist in Discovery Biology to support target validation and drug development within a research-focused oncology environment. The role involves designing and executing cell-based and mechanistic experiments across cell biology, cellular biochemistry, and molecular biology, with a focus on ubiquitin biology and cell signaling, while collaborating cross-functionally with bioinformatics, chemistry, and HTS teams. Candidates must hold at least a Bachelor's degree with 5+ years of relevant experience (or advanced degree with less experience), and should have hands-on proficiency with mammalian cell culture, CRISPR/Cas9, immunoprecipitation, flow cytometry, confocal microscopy, and functional assays. Experience in drug discovery for solid tumors, protein degrader development, and data analysis tools such as GraphPad Prism and FlowJo is strongly preferred. The ideal candidate is a strong communicator who can deliver high-quality, organized data in a fast-paced, collaborative team setting.Position Responsibilities In the role as Scientist within the Discovery Biology department, the ideal candidate:Develops and implements cell-based assays to support target validation and drug developmentDesigns and conducts essential mechanistic experiments in cell biology, cellular biochemistry, and molecular biologyApplies experience and expertise in ubiquitin biology and cell signaling to develop new approaches and technologies to support drug discovery and developmentConducts experiments in close collaboration with bioinformatics, chemistry, and HTS groupsAccurately maintains written reports and presents information to convey clear, key messages in an organized and timely mannerMay represent department on project team or sub-teamExperience =Basic Qualifications: Bachelor’s Degree5+ years of academic and / or industry experienceOrMaster’s Degree3+ years of academic and / or industry experienceOrPh.D. or equivalent advanced degree in the Life SciencesNo experience necessaryPreferred Qualifications: Hands-on experience with mammalian cell culture, molecular and cellular technologies (e.g. CRISPR/Cas9 knock-out, lentivirus transduction, western blotting, JESS automated western blot system, pull-down assays, immunoprecipitation, proximity ligation assay, quantitative PCR, flow cytometry, confocal microscopy) and functional assays (e.g. proliferation, apoptosis, cell cycle, protein-protein interactions) is essential.Prior experience of working on drug discovery projects for solid tumors in an industrial or an academic setting is preferred.Experience with development of protein degraders and/or solid tumor models is a plus.Proficiency in scientific data analysis programs including GraphPad Prism, FlowJo, Microsoft Excel and Powerpoint, is required.Capability to deliver high quality data in an organized and timely manner.Ability to work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude and independently collaborate across teams, requiring excellent communication skills, both written and verbal, with strong interpersonal skills.#LI-OnsiteIf you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.Compensation Overview:San Diego - CA - US: $118,750 - $143,901 The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/. Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:Health Coverage: Medical, pharmacy, dental, and vision care.Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection,