Senior Principal Scientist – DMPK Project Representative

Working with UsChallenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.Position SummaryWe seek an innovative, self-motivated, exceptional scientist to join our Drug Metabolism and Pharmacokinetic (DMPK) department at our Cambridge, MA site. The role is a senior scientific leader responsible for shaping DMPK strategy across oligonucleotide discovery programs from target validation through candidate selection. This role provides strategic leadership in ADME, pharmacokinetics, PK/PD, and translational science, influences compound design and progression, and represents DMPK on multidisciplinary teams to support high-quality decision-making across the portfolio. Key ResponsibilitiesLead DMPK strategy for oligonucleotide discovery programs from early discovery through candidate nomination, identifying risks and enabling data-driven decisions. Provide modality-specific expertise in oligonucleotide disposition, including tissue distribution, uptake, metabolism, stability, and exposure-response relationships. Design and interpret in vitro and in vivo DMPK studies and integrate findings from bioanalysis, pharmacology, and toxicology to guide compound optimization.Apply translational and model-informed approaches to predict human PK/PD, dose, and regimen strategies for ASO therapeutics. Represent DMPK on cross-functional teams, influence portfolio decisions, and mentor scientists while advancing innovative platform capabilities. Qualifications & ExperiencePh.D. in pharmacokinetics, drug metabolism, pharmacology, or related discipline with 6+ years of industrial experienceDeep expertise in ADME, PK/PD modelling with experience in Oligonucleotide / ASO pharmacokinetics and dispositionDemonstrated ability to lead and influence drug discovery programs and candidate selectionExcellent interpersonal, organizational, oral/written communication skillsA strong team player with ability to collaborate and build trustworthy relationships with other disciplines for idea generation, issue resolution and program advancement#LI-OnsiteIf you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.Compensation Overview:Cambridge Crossing: $194,710 - $235,942 The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/. Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:Health Coverage: Medical, pharmacy, dental, and vision care.Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.​Work-life benefits include:Paid Time OffUS Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidaysBased on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.*Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.Uniquely Interest